The Arctic is deeply entangled with world politics and the large global challenges of our time. Climate change and global warming have a profound impact on Arctic geographies, societies, and ways of life. Growing external interest in the region’s natural resources and transport routes has moved the region into the epicenter of broad geopolitical concerns and global divisions and tensions. Yet, knowledge and experiences of Arctic peoples, societies and communities, including Indigenous peoples, can profoundly challenge these dominant narratives and framings of the Arctic, and provide alternative, decolonial, and critical perspectives and agency to world politics and global change. Never has there been such demand for new, multidisciplinary knowledge on the Arctic region and its connections to the rest of the world.